I received my Ph.D. in Anatomy and Cognitive Neuroscience from the VU University medical center, Amsterdam, The Netherlands. During my career I have actively pursued a comparative anatomical view on neuroscience and focused specifically on the anatomy, connectivity and function of the hippocampal formation and parahippocampal region of rats and humans. I have hands on experience with tract-tracing in rodents as well as with animal and human magnetic resonance imaging. This experience enables me to have an integral view on otherwise quite independent research lines, which remain in relative isolation because of incompatibilities between nomenclatures and scientific procedures. To carry out my research, I was awarded a personal post-doctoral fellowship from the Norwegian Research Council. During my post-doc I was appointed at the Medical Imaging lab (fMRI group) of the Norwegian University of Science and Technology (NTNU), Trondheim and worked on projects in close collaboration with the Centre for the Biology of Memory. During this period I carried out a large scale functional MRI study on human schema memory, which is currently in the last phase of analysis. At the same time I developed a web portal for our connectivity database project at www.temporal-lobe.com and based on our experiences with collating connectivity data of the rat, together with Dr Cappaert and a subcontracted database expert, I created an improved database suitable to store connectivity data of all species at a high level of detail. Finally, I just finished updating a book section about the rat hippocampal formation and parahippocampal region in the 4thedition of the reference work “The Rat Nervous System” (link is to the 3rd edition), which is due to appear in November 2013. Currently, I am employed as a researcher at the Kavli Institute for Systems Neuroscience and Centre for Neural Computation and am finishing up the analysis of human functional imaging datasets as well as a graph analysis on the connectivity database. Also I will develop a lab-routine through which digitized histological sections can be digitized, stored and annotated in the Norwegian High Performance Computing storage (NorStor) cluster and a procedure that will allow these images to be three-dimensionally reconstructed and registered to the rat Waxholm space.
Niels van Strien, PhD
Functional MRI group, Medical Imaging Lab
St Olavs's Hospital, Norwegian University of Science and Technology (NTNU)
NO-7006 Trondheim, Norway
Email: niels.v.strien at(@) ntnu.no
Graph analysis of the anatomical network organization of the hippocampal formation and parahippocampal region in the rat.
Related Articles Graph analysis of the anatomical network organization of the hippocampal formation and parahippocampal region in the rat. Brain Struct Funct. 2015 Jan 25; Authors: Binicewicz FZ, van Strien NM, Wadman WJ, van den Heuvel MP, Cappaert NL Abstract Graph theory was used to analyze the anatomical network of the rat hippocampal formation and the parahippocampal region (van Strien et al., Nat Rev Neurosci 10(4):272-282, 2009). For this analysis, the full network was decomposed along the three anatomical axes, resulting in three networks that describe the connectivity within the rostrocaudal, dorsoventral and laminar dimensions. The rostrocaudal network had a connection density of 12 % and a path length of 2.4. The dorsoventral network had a high cluster coefficient (0.53), a relatively high path length (1.62) and a rich club was identified. The modularity analysis revealed three modules in the dorsoventral network. The laminar network contained most information. The laminar dimension revealed a network with high clustering coefficient (0.47), a relatively high path length (2.11) and four significantly increased characteristic network building blocks (structural motifs). Thirteen rich club nodes were identified, almost all of them situated in the parahippocampal region. Six connector hubs were detected and all of them were located in the entorhinal cortex. Three large modules were revealed, indicating a close relationship between the perirhinal and postrhinal cortex as well as between the lateral and medial entorhinal cortex. These results confirmed the central position of the entorhinal cortex in the (para)hippocampal network and this possibly explains why pathology in this region has such profound impact on cognitive function, as seen in several brain diseases. The results also have implications for the idea of strict separation of the "spatial" and the "non-spatial" information stream into the hippocampus. This two-stream memory model suggests that the information influx from, respectively, the postrhinal-medial entorhinal cortex and the perirhinal-lateral entorhinal cortex is separate, but the current analysis shows that this apparent separation is not determined by anatomical constraints. PMID: 25618022 [PubMed - as supplied by publisher]