Menno Witter was born in The Netherlands in 1953. He did his PhD with professors Anthony Lohman and Fernando Lopes da Silva at the VU University and VU medical center in Amsterdam, where he published the first detailed anatomical account of the organization of the entorhinal cortex, focusing on its role in hippocampal-cortical interactions (1985). After his Ph.D., he worked with David Amaral and Gary VanHoesen in the US (1985/1986) on the organization of the entorhinal-hippocampal system in primates and continued to work as assistant professor in the department of Anatomy at the Vrije University. In 1989 he published two influential papers on the anatomy of the cortico-hippocampal system, which still are considered 'classics' in the field. In these papers he proposed functional differentiation within the hippocampus and parahippocampus, an issue which is now at the heart of some of the more promising research lines in the hippocampal field. In 1990, together with David Amaral, he initiated the launch of the journal Hippocampus, which, now being in its 19th year, is a major vehicle for communication among scientists in the field. As of 1990, he headed his own research group, focusing on the functional organization of the medial temporal lobe (MTL), in particular in relation to learning and memory and Alzheimer's disease. In 1993, he worked as a visiting scientist and senior consultant with Prof. Dr. G. Matsumoto and Dr. T. Iijima, ETL, Tsukuba, Japan, where he started to use voltage-sensitive dye imaging to study network properties of the hippocampal-parahippocampal system. This powerful approach resulted in the description of networks potentially mediating reverberation, a proposed mechanism for memory storage. This collaboration has continued over the years, focusing on possible interactions between multiple input pathways onto identified neuronal populations.
In 1995, he was appointed as full professor in Anatomy and Embryology at the VU University Medical Center where he continued his work on functional anatomy of the cortico-hippocampal system, combined with in vivo electrophysiology and human functional MRI studies. He contributed significantly to our understanding of parallel input-output pathways between the parahippocampal region and the hippocampus, and the possibility of functional heterogeneity between hippocampal and parahippocampal subfields as well as within the individual subfields. In addition, on the basis of clinical and experimental data, he published a series of influential papers on the role of the midline and intralaminar thalamus in cognition and its contribution to diencephalic amnesia and frontal syndromes. In 1999 he was appointed as scientific director of the Institute for Neuroscience of the VU/VUmc and as director of the Graduate School Neuroscience Amsterdam. He was one of the founding directors of the Center for Neurogenomics and Cognitive Research VU/Vumc (2003).
In 2004 he was appointed as visiting professor in the Centre for the Biology of Memory and the Kavli Institute for Systems Neuroscience at the Norwegian University for Science and Technology (NTNU) in Trondheim. In 2007 he moved to Trondheim, where he continues his work on functional anatomy of the cortico-hippocampal system, relevant to memory processes in particular to spatial memory and navigation. He combines anatomical approaches with in vitro electrophysiology. His current research interests include the study of functional differentiation between cell types and cell layers in the entorhinal cortex, structural and connectional differences between the lateral and medial entorhinal cortex and the development of the entorhinal cortex and its connections. He is also involved in human functional MRI studies that focus on understanding functional heterogeneity within the human MTL.
- Elected member of The Royal Norwegian Society of Sciences and Letters (Det Kongelige Norske Videnskabers Selskab)
- The Norwegian Academy of Science (Det Norske Vitensskaps-Akademi).
- Member of the editorial boards of Hippocampus and Brain Structure and Function.
- Section editor Neuroanatomy for Neuroscience and associate editor for Frontiers in Neuroanatomy.
- Visiting Professor, Graduate school for Life Sciences, Tohoku University, Sendai, Japan.
- Invited Lecturer Graduate Program Neuroscience, Univ. Murcia, Spain
Menno Witter, PhD
Professor Neuroscience, Dept. Neuroscience
Kavli Institute for Systems Neuroscience, Centre for the Biology of Memory
MTFS, Norwegian University of Science and Technology (NTNU)
NO-7489 Trondheim, Norway
Phone: +47 73598249
Fax: +47 73598294
Email: menno.witter at(@) ntnu.no
Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease.
Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease. Neurobiol Dis. 2016 May 16; Authors: Kobro-Flatmoen A, Nagelhus A, Witter MP Abstract The onset of Alzheimer's disease (AD) is associated with subtle pathological changes including increased intracellular expression of amyloid-β (Aβ). A structure affected particularly early in the course of AD is the entorhinal cortex, where neuronal death in layer II is observed already at initial stages. Neurons in EC-layer II, particularly those that express the protein Reelin, give rise to projections to the hippocampal dentate gyrus and this projection shows severe loss of synaptic contacts during early-stage AD. Given this anatomical specificity, we sought to determine whether increased intracellular expression of Aβ is selectively associated with Reelin-immunoreactive neurons in layer II of the entorhinal cortex. Here we report that in a transgenic rat model, which mimics the onset and distribution of extracellular amyloid deposits seen in human AD subjects, expression of intracellular Aβ in entorhinal layer II selectively occurs in Reelin-immunoreactive neurons during the early, pre-plaque stage. This Reelin-Aβ association is also present in human subjects with AD-related pathological changes, even in early disease stages. These findings strongly indicate that Reelin-immunoreactive neurons in entorhinal layer II play a crucial role during the initial stages of AD, and may therefore lead to refined hypotheses concerning the origin of this devastating condition. PMID: 27195475 [PubMed - as supplied by publisher]