Kally O’Reilly earned her PhD in Cellular and Molecular Biology at the University of Texas at Austin in Texas in 2008. Her thesis work focused on pharmacological induced changes in depression-related behaviors and neural network interactions in the adolescent mouse brain. She then started her postdoctoral work with Menno Witter at the Kavli Institute for Systems Neuroscience/Centre for the Biology of Memory at the Norwegian University of Science and Technology (NTNU) in Trondheim Norway. Her postdoctoral research examines the development of hippocampal/parahippocampal regions. She has focused on early postnatal development of connections using traditional retrograde and anterograde tracing techniques. The need to delineate hippocampal/parahippocampal regions for her studies has led to the synthesis of the neonatal atlas with chemoarchitectonic markers.
Contact Details
Kally C. O’Reilly, PhD
Postdoctor – Witter Group
Kavli Institute for Systems Neuroscience, Centre for the Biology of Memory
MTFS, Norwegian University of Science and Technology (NTNU)
NO-7489 Trondheim, Norway
Email: kally.oreilly at(@)ntnu.no
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Development and Topographic Organization of Subicular Projections to Lateral Septum in the Rat Brain.
Related Articles Development and Topographic Organization of Subicular Projections to Lateral Septum in the Rat Brain. Eur J Neurosci. 2020 Feb 06;: Authors: Tsamis KI, Lagartos Donato MJ, Dahl AG, O'Reilly KC, Witter MP Abstract One of the main subcortical targets of hippocampal formation efferents is the lateral septum. Previous studies on the subicular projections, as a main output structure of the hippocampus, have shown a clear topographic organization of septal innervation, related to the origin of the fibers along the dorsoventral axis of the subiculum in the adult brain. In contrast, studies on the developing brain depict an extensive rearrangement of subicular projections during the prenatal period, shifting from the medial to the lateral septum. Our study aimed to describe the postnatal development of subicular projections to the septum. We injected anterograde tracers into the subiculum of 57 pups of different postnatal age. Injections covered the proximo-distal and dorso-ventral axis of the subiculum. The age of the pups at day of tracer injection ranged from the day of birth to postnatal day 30. Analyses revealed that from the first postnatal day projections from subiculum preferentially target the lateral septum. Sparse innervation in the lateral septum was already present in the first few postnatal days and during the following 3 weeks the axonal distribution gradually expanded. Subicular projections to the lateral septum are topographically organized depending on the origin along the dorso-ventral axis of the subiculum, in line with the adult innervation pattern. Different origins along the proximo-distal axis of the subiculum are reflected in changes in the strength of septal innervation. The findings demonstrate that in case of the development of subicular projections, axonal expansion is more prominent than axonal pruning. PMID: 32027422 [PubMed - as supplied by publisher]
