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Dr. NLM Cappaert

Natalie Cappaert is an Assistant Professor at the Swammerdam Institute for Life Sciences, University of Amsterdam, the Netherlands. Her thesis work was carried out in the Hearing Research Laboratories of the University of Utrecht. During her postdoctoral training her interest shifted toward the central nervous system. In her recent research on the network properties of the hippocampus and the entorhinal cortex, she has applied a combination of in vitro voltage sensitive dye imaging and extracellular recordings. In her VENI project (2004-2007) she studied theta oscillations and functional connectivity. In current project, the micro-circuitry of the perirhinal cortex is characterized, in particular to understand the functioning of the perirhinal gate, by investigating the relations between the participating excitatory and inhibitory neurons and their intercommunication.

To better understand the network properties, she also studies anatomical connectivity of the hippocampus and parahippocampal region, together with Prof. Menno Witter (Kavli Institute, Norwegian University of Science and Technology, Trondheim) and Niels van Strien (Kavli Institute) by developing an interactive connectome of the three-dimensional organization of the projection patterns between and within the hippocampal formation, the parahippocampal region and the retrosplenial cortex (Van Strien et al., 2009). The functional properties of this structural connectome were investigated with a graph analysis (Biniciewicz et al., 2016).

Contact Details

Natalie L.M. Cappaert, PhD
Assistant professor
University of Amsterdam
Swammerdam Institute for Life Sciences
Sciencepark 904
1098 XH Amsterdam, The Netherlands
Email: n.cappaert at(@) uva.nl

Personal website: http://www.uva.nl/contact/medewerkers/item/n.cappaert.html?f=cappaert

Meeting/Conference Poster/Abstract
Posters & Abstracts Click link to download (opens in new window).
SFN 2012 N.L.M. Cappaert, M.P. Witter, N.M. van Strien. 2012. New features in the 2012 release of the open source (para)hippocampal connectome of the rat. Poster at the Society for Neuroscience conference, New Orleans, USA.
SFN 2011 J. Sugar, M.P. Witter, N.M. van Strien, N. Cappaert. 2011. “The retrosplenial cortex: Intrinsic connectivity and connections with the (para)hippocampal region in the rat. An interactive connectome.” Poster at the Society for Neuroscience conference, Washington, USA.
FENS 2010 NLM Cappaert, TR Werkman, JC Baayen, MP Witter , R de Haan, WJ Wadman. 2010. "Evoked responses in hippocampal dentate gyrus tissue of epileptic patients: A voltage Sensitive dye imaging stud." Poster at the Federation of European Neurosciences conference, Amsterdam, The Netherlands.
SFN 2006 Natalie L.M. Cappaert & Wytse J. Wadman. 2006. “ Propagation and synchronization of theta oscillations the hippocampus and entorhinal cortex of the rat in vitro”. Poster at the Society for Neuroscience conference, USA.
SFN 2005 Natalie L.M. Cappaert, Wytse J. Wadman, Menno P. Witter. 2005. “Spatiotemporal analyses of interactions between entorhinal and CA1 projections to the subiculum of the rat”. Poster at the Society for Neuroscience conference, USA.

pubmed: cappaert n[author]

NCBI: db=pubmed; Term=cappaert N[Author] NCBI pubmed
  • Related Articles Parvalbumin interneuron mediated feedforward inhibition controls signal output in the deep layers of the perirhinal-entorhinal cortex. Hippocampus. 2018 Jan 17;: Authors: Willems JGP, Wadman WJ, Cappaert NLM Abstract The perirhinal (PER) and lateral entorhinal (LEC) cortex form an anatomical link between the neocortex and the hippocampus. However, neocortical activity is transmitted through the PER and LEC to the hippocampus with a low probability, suggesting the involvement of the inhibitory network. This study explored the role of interneuron mediated inhibition, activated by electrical stimulation in the agranular insular cortex (AiP), in the deep layers of the PER and LEC. Activated synaptic input by AiP stimulation rarely evoked action potentials in the PER-LEC deep layer excitatory principal neurons, most probably because the evoked synaptic response consisted of a small excitatory and large inhibitory conductance. Furthermore, parvalbumin positive (PV) interneurons - a subset of interneurons projecting onto the axo-somatic region of principal neurons - received synaptic input earlier than principal neurons, suggesting recruitment of feedforward inhibition. This synaptic input in PV interneurons evoked varying trains of action potentials, explaining the fast rising, long lasting synaptic inhibition received by deep layer principal neurons. Altogether, the excitatory input from the AiP onto deep layer principal neurons is overruled by strong feedforward inhibition. PV interneurons, with their fast, extensive stimulus-evoked firing, are able to deliver this fast evoked inhibition in principal neurons. This indicates an essential role for PV interneurons in the gating mechanism of the PER-LEC network. This article is protected by copyright. All rights reserved. PMID: 29341361 [PubMed - as supplied by publisher]

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