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Dr. NLM Cappaert

Natalie Cappaert is an Assistant Professor at the Swammerdam Institute for Life Sciences, University of Amsterdam, the Netherlands. Her thesis work was carried out in the Hearing Research Laboratories of the University of Utrecht. During her postdoctoral training her interest shifted toward the central nervous system. In her recent research on the network properties of the hippocampus and the entorhinal cortex, she has applied a combination of in vitro voltage sensitive dye imaging and extracellular recordings. In her VENI project (2004-2007) she studied theta oscillations and functional connectivity. In current project, the micro-circuitry of the perirhinal cortex is characterized, in particular to understand the functioning of the perirhinal gate, by investigating the relations between the participating excitatory and inhibitory neurons and their intercommunication.

To better understand the network properties, she also studies anatomical connectivity of the hippocampus and parahippocampal region, together with Prof. Menno Witter (Kavli Institute, Norwegian University of Science and Technology, Trondheim) and Niels van Strien (Kavli Institute) by developing an interactive connectome of the three-dimensional organization of the projection patterns between and within the hippocampal formation, the parahippocampal region and the retrosplenial cortex (Van Strien et al., 2009). The functional properties of this structural connectome were investigated with a graph analysis (Biniciewicz et al., 2016).

Contact Details

Natalie L.M. Cappaert, PhD
Assistant professor
University of Amsterdam
Swammerdam Institute for Life Sciences
Sciencepark 904
1098 XH Amsterdam, The Netherlands
Email: n.cappaert at(@) uva.nl

Personal website: http://www.uva.nl/contact/medewerkers/item/n.cappaert.html?f=cappaert

Meeting/Conference Poster/Abstract
Posters & Abstracts Click link to download (opens in new window).
SFN 2012 N.L.M. Cappaert, M.P. Witter, N.M. van Strien. 2012. New features in the 2012 release of the open source (para)hippocampal connectome of the rat. Poster at the Society for Neuroscience conference, New Orleans, USA.
SFN 2011 J. Sugar, M.P. Witter, N.M. van Strien, N. Cappaert. 2011. “The retrosplenial cortex: Intrinsic connectivity and connections with the (para)hippocampal region in the rat. An interactive connectome.” Poster at the Society for Neuroscience conference, Washington, USA.
FENS 2010 NLM Cappaert, TR Werkman, JC Baayen, MP Witter , R de Haan, WJ Wadman. 2010. "Evoked responses in hippocampal dentate gyrus tissue of epileptic patients: A voltage Sensitive dye imaging stud." Poster at the Federation of European Neurosciences conference, Amsterdam, The Netherlands.
SFN 2006 Natalie L.M. Cappaert & Wytse J. Wadman. 2006. “ Propagation and synchronization of theta oscillations the hippocampus and entorhinal cortex of the rat in vitro”. Poster at the Society for Neuroscience conference, USA.
SFN 2005 Natalie L.M. Cappaert, Wytse J. Wadman, Menno P. Witter. 2005. “Spatiotemporal analyses of interactions between entorhinal and CA1 projections to the subiculum of the rat”. Poster at the Society for Neuroscience conference, USA.

pubmed: cappaert n[author]

NCBI: db=pubmed; Term=cappaert N[Author] NCBI pubmed
  • Related Articles Interaction of cortical and amygdalar synaptic input modulates the window of opportunity for information processing in the rhinal cortices. eNeuro. 2019 Aug 06;: Authors: Willems JGP, Wadman WJ, Cappaert NLM Abstract The perirhinal (PER) and lateral entorhinal (LEC) cortex function as a gateway for information transmission between (sub)cortical areas and the hippocampus. It is hypothesized that the amygdala, a key structure in emotion processing, can modulate PER-LEC neuronal activity before information enters the hippocampal memory pathway. This study determined the integration of synaptic activity evoked by simultaneous neocortical and amygdala electrical stimulation in PER-LEC deep layer principal neurons and PV interneurons in mouse brain slices. The data revealed that both deep layer PER-LEC principal neurons and PV interneurons receive synaptic input from the neocortical agranular insular cortex (AiP) and the lateral amygdala (LA). Furthermore, simultaneous stimulation of the AiP and LA never reached the firing threshold in principal neurons of the PER-LEC deep layers. PV interneurons however, mainly showed linear summation of simultaneous AiP and LA inputs and reached their firing threshold earlier. This early PV firing was reflected in the forward shift of the evoked inhibitory conductance in principal neurons, thereby creating a more precise temporal window for coincidence detection which likely plays a crucial role in information processing.Significance Statement The perirhinal and lateral entorhinal cortices (PER-LEC) function as a gateway for information transmission between the neocortex and the hippocampus and this information flow can be modulated by the amygdala. Here, we showed that simultaneous input of the neocortex and the amygdala coincided onto principal neurons and PV interneurons of the PER-LEC deep layers. PV interneurons linearly summated these synaptic inputs and reached their firing threshold earlier. This earlier PV firing resulted in an earlier rise of the inhibitory conductance in principal neurons, likely causing a more precise temporal window for excitatory coincidence detection. This process probably indicates a significant role for the inhibitory network in regulating integration of emotion and information for processing in the PER-LEC deep layer network. PMID: 31387874 [PubMed - as supplied by publisher]

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