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Dr. NLM Cappaert

Natalie Cappaert is an Assistant Professor at the Swammerdam Institute for Life Sciences, University of Amsterdam, the Netherlands. Her thesis work was carried out in the Hearing Research Laboratories of the University of Utrecht. During her postdoctoral training her interest shifted toward the central nervous system. In her recent research on the network properties of the hippocampus and the entorhinal cortex, she has applied a combination of in vitro voltage sensitive dye imaging and extracellular recordings. In her VENI project (2004-2007) she studied theta oscillations and functional connectivity. In current project, the micro-circuitry of the perirhinal cortex is characterized, in particular to understand the functioning of the perirhinal gate, by investigating the relations between the participating excitatory and inhibitory neurons and their intercommunication.

To better understand the network properties, she also studies anatomical connectivity of the hippocampus and parahippocampal region, together with Prof. Menno Witter (Kavli Institute, Norwegian University of Science and Technology, Trondheim) and Niels van Strien (Kavli Institute) by developing an interactive connectome of the three-dimensional organization of the projection patterns between and within the hippocampal formation, the parahippocampal region and the retrosplenial cortex (Van Strien et al., 2009). The functional properties of this structural connectome were investigated with a graph analysis (Biniciewicz et al., 2016).

Contact Details

Natalie L.M. Cappaert, PhD
Assistant professor
University of Amsterdam
Swammerdam Institute for Life Sciences
Sciencepark 904
1098 XH Amsterdam, The Netherlands
Email: n.cappaert at(@) uva.nl

Personal website: http://www.uva.nl/contact/medewerkers/item/n.cappaert.html?f=cappaert

Meeting/Conference Poster/Abstract
Posters & Abstracts Click link to download (opens in new window).
SFN 2012 N.L.M. Cappaert, M.P. Witter, N.M. van Strien. 2012. New features in the 2012 release of the open source (para)hippocampal connectome of the rat. Poster at the Society for Neuroscience conference, New Orleans, USA.
SFN 2011 J. Sugar, M.P. Witter, N.M. van Strien, N. Cappaert. 2011. “The retrosplenial cortex: Intrinsic connectivity and connections with the (para)hippocampal region in the rat. An interactive connectome.” Poster at the Society for Neuroscience conference, Washington, USA.
FENS 2010 NLM Cappaert, TR Werkman, JC Baayen, MP Witter , R de Haan, WJ Wadman. 2010. "Evoked responses in hippocampal dentate gyrus tissue of epileptic patients: A voltage Sensitive dye imaging stud." Poster at the Federation of European Neurosciences conference, Amsterdam, The Netherlands.
SFN 2006 Natalie L.M. Cappaert & Wytse J. Wadman. 2006. “ Propagation and synchronization of theta oscillations the hippocampus and entorhinal cortex of the rat in vitro”. Poster at the Society for Neuroscience conference, USA.
SFN 2005 Natalie L.M. Cappaert, Wytse J. Wadman, Menno P. Witter. 2005. “Spatiotemporal analyses of interactions between entorhinal and CA1 projections to the subiculum of the rat”. Poster at the Society for Neuroscience conference, USA.

pubmed: cappaert n[author]

NCBI: db=pubmed; Term=cappaert N[Author] NCBI pubmed
  • Related Articles Excitation-inhibition dynamics regulate activity transmission through the perirhinal - entorhinal network. Neuroscience. 2019 May 24;: Authors: Willems JGP, Wadman WJ, Cappaert NLM Abstract The perirhinal (PER) - lateral entorhinal (LEC) network plays a pivotal role in the information transfer between the neocortex and the hippocampus. Anatomical studies have shown that the connectivity is organized bi-directionally: the superficial layers consist of projections running from the neocortex via the PER-LEC network to the hippocampus while the deep layers form the output pathway back to the neocortex. Although these pathways are characterized anatomically, the functional organization of the superficial and deep connections in the PER-LEC network remains to be revealed. We performed paired recordings of superficial and deep layer principal neurons and found that a larger population of superficial neurons responded with action potential firing in response to superficial cortical input, compared to the deep layer population. This suggested that the superficial network can carry information from the cortex towards the hippocampus. The relation between the excitatory and inhibitory input onto the deep and superficial principal neurons showed that the window of net excitability was larger in superficial principal neurons. We performed paired recordings in superficial layer principal neurons and parvalbumin (PV) expressing interneurons to address how this window of opportunity for spiking is affected in superficial principal neurons. The PV interneuron population initiated inhibition at a very consistent timing with increasing stimulus intensity, whereas the excitation temporally shifted to ensure action potential firing. These data indicate that superficial principal neurons can transmit cortical synaptic input through the PER-LEC network because these neurons have a favorable window of opportunity for spiking in contrast to deep neurons. PMID: 31132396 [PubMed - as supplied by publisher]

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