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I received my Ph.D. in Anatomy and Cognitive Neuroscience from the VU University medical center, Amsterdam, The Netherlands. During my career I have actively pursued a comparative anatomical view on neuroscience and focused specifically on the anatomy, connectivity and function of the hippocampal formation and parahippocampal region of rats and humans. I have hands on experience with tract-tracing in rodents as well as with animal and human magnetic resonance imaging. This experience enables me to have an integral view on otherwise quite independent research lines, which remain in relative isolation because of incompatibilities between nomenclatures and scientific procedures. To carry out my research, I was awarded a personal post-doctoral fellowship from the Norwegian Research Council. During my post-doc I was appointed at the Medical Imaging lab (fMRI group) of the Norwegian University of Science and Technology (NTNU), Trondheim and worked on projects in close collaboration with the Centre for the Biology of Memory. I currently hold a postdoc position at the University of Amsterdam in which I aim to unravel the mechanism by which the amygdala modulates the hippocampal network by using a computational model that mimics the known anatomical connectivity and simulates the dynamic modulation by rhythmic brain activity.

Contact details

Niels van Strien, PhD
University of Amsterdam
Faculty of Science
PO Box 94215 | 1090 GE Amsterdam
REC G0.06 - Nieuwe Achtergracht 129 | Amsterdam | The Netherlands


Meeting/Conference Poster/Abstract
Posters & Abstracts Click link to download (opens in new window).
SFN 2012 N.L.M. Cappaert, M.P. Witter, N.M. van Strien. 2012. New features in the 2012 release of the open source (para)hippocampal connectome of the rat. Poster at the Society for Neuroscience conference, New Orleans, USA.
SFN 2012 H. Lehn, A.K. Håberg, M.P. Witter, G. Fernandez, R.G.M. Morris, N.M. van Strien. 2012. Schema effects on learning and memory. Poster at the Society for Neuroscience conference, New Orleans, USA.
SFN 2011 N.M. van Strien. N. Tustison, S.Das, B. Avants. 2011. “An open-source pipeline for minimizing anatomical variability in multi-subject functional MRI analysis”. Poster at the Society for Neuroscience conference, Washington, USA.
SFN 2011 J. Sugar, M.P. Witter, N.M. van Strien, N. Cappaert. 2011. “The retrosplenial cortex: Intrinsic connectivity and connections with the (para)hippocampal region in the rat. An interactive connectome.” Poster at the Society for Neuroscience conference, Washington, USA.

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van strien n[author] not "the status of the world's land and m...: Latest results from PubMed
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  • Graph theory was used to analyze the anatomical network of the rat hippocampal formation and the parahippocampal region (van Strien et al., Nat Rev Neurosci 10(4):272-282, 2009). For this analysis, the full network was decomposed along the three anatomical axes, resulting in three networks that describe the connectivity within the rostrocaudal, dorsoventral and laminar dimensions. The rostrocaudal network had a connection density of 12% and a path length of 2.4. The dorsoventral network had a...

  • Many studies of the human brain have explored the relationship between cortical thickness and cognition, phenotype, or disease. Due to the subjectivity and time requirements in manual measurement of cortical thickness, scientists have relied on robust software tools for automation which facilitate the testing and refinement of neuroscientific hypotheses. The most widely used tool for cortical thickness studies is the publicly available, surface-based FreeSurfer package. Critical to the adoption...

  • No abstract

  • A connectome is an indispensable tool for brain researchers, since it quickly provides comprehensive knowledge of the brain's anatomical connections. Such knowledge lies at the basis of understanding network functions. Our first comprehensive and interactive account of brain connections comprised the rat hippocampal-parahippocampal network. We have now added all anatomical connections with the retrosplenial cortex (RSC) as well as the intrinsic connections of this region, because of the...

  • Converging evidence suggests that each parahippocampal and hippocampal subregion contributes uniquely to the encoding, consolidation and retrieval of declarative memories, but their precise roles remain elusive. Current functional thinking does not fully incorporate the intricately connected networks that link these subregions, owing to their organizational complexity; however, such detailed anatomical knowledge is of pivotal importance for comprehending the unique functional contribution of...

  • There is a growing interest in how temporal order of episodic memories is represented within the medial temporal lobe (MTL). Animal studies suggest that the hippocampal formation (HF) is critical for retrieving the temporal order of past experiences. However, human imaging studies that have tested recency discrimination between pairs of previously encoded items have generally failed to report HF activation. We hypothesized that recalling a naturalistic sequence of past events would be...

  • Knowledge of mammalian diversity is still surprisingly disparate, both regionally and taxonomically. Here, we present a comprehensive assessment of the conservation status and distribution of the world's mammals. Data, compiled by 1700+ experts, cover all 5487 species, including marine mammals. Global macroecological patterns are very different for land and marine species but suggest common mechanisms driving diversity and endemism across systems. Compared with land species, threat levels are...

  • The perirhinal cortex (PER) is part of both the medial temporal lobe memory system (MTL) and the ventral visual stream (VVS). In the MTL, PER provides input to the hippocampal formation directly and via the entorhinal cortex (EC), whereas in the VVS, PER is considered to be at the top of the visual processing hierarchy of object information. Because of its position in both networks, PER presumably serves a role in memory and visual perception. PER's perceptual role is thought to be contingent...

  • Several structural brain abnormalities have been reported in patients with Attention Deficit Hyperactivity Disorder (ADHD). However, the etiology of these brain changes is still unclear. To investigate genetic and environmental influences on ADHD related neurobiological changes, we performed Voxel-Based Morphometry on MRI scans from monozygotic (MZ) twins selected from a large longitudinal population database to be highly concordant or highly discordant for ratings on the Child Behavior...

  • Learning-induced synaptic plasticity commonly involves the interaction between cAMP and p42/44MAPK. To investigate the role of Rap1 as a potential signaling molecule coupling cAMP and p42/44MAPK, we expressed an interfering Rap1 mutant (iRap1) in the mouse forebrain. This expression selectively decreased basal phosphorylation of a membrane-associated pool of p42/44MAPK, impaired cAMP-dependent LTP in the hippocampal Schaffer collateral pathway induced by either forskolin or theta frequency...

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